Climbazole

In the following article, we will explore the topic of Climbazole from different perspectives and approaches. _Var1 is a topic that has sparked interest and debate over time, and its relevance and impact extends to various areas of daily life. Through a detailed and exhaustive analysis, we will take a look at the history, current trends, and future of Climbazole, as well as its influence on society in general. With interviews with experts, relevant data and illustrative examples, we aim to offer a complete and enlightening vision of this fascinating and important topic.
Climbazole
Clinical data
Routes of
administration		topical
ATC code
  • none
Identifiers
  • (RS)-1-(4-Chlorophenoxy)-1-imidazol-1-yl-3,3-dimethylbutan-2-one
CAS Number
PubChem CID
ChemSpider
UNII
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.048.870 Edit this at Wikidata
Chemical and physical data
FormulaC15H17ClN2O2
Molar mass292.76 g·mol−1
3D model (JSmol)
ChiralityRacemic mixture
  • CC(C)(C)C(=O)C(n1ccnc1)Oc2ccc(cc2)Cl
  • InChI=1S/C15H17ClN2O2/c1-15(2,3)13(19)14(18-9-8-17-10-18)20-12-6-4-11(16)5-7-12/h4-10,14H,1-3H3 ☒N
  • Key:OWEGWHBOCFMBLP-UHFFFAOYSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

Climbazole is a topical antifungal agent commonly used in the treatment of human fungal skin infections such as dandruff, seborrhoeic dermatitis and eczema. Climbazole has shown a high in vitro and in vivo efficacy against Malassezia spp. that appear to play an important role in the pathogenesis of dandruff. Its chemical structure and properties are similar to other azole fungicides such as ketoconazole, clotrimazole and miconazole.

Indications and formulations

It is most commonly found as an active ingredient in OTC anti-dandruff and anti-fungal products, including shampoos, lotions and conditioners. It may be accompanied by other active ingredients such as zinc pyrithione or triclosan.[citation needed]

Side effects

It may cause localized irritation of the skin with symptoms including redness, rashes and itching.[citation needed]

References

  1. ^ Chemical Properties of Climbazole Archived 2007-11-13 at the Wayback Machine
  2. ^ a b Wigger-Alberti W, Kluge K, Elsner P (August 2001). "". Praxis. 90 (33): 1346–9. PMID 11534318.
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