Omega-Atracotoxin

In today's world, Omega-Atracotoxin is a topic that has captured the attention of millions of people around the world. From its impact on society to its influence on popular culture, Omega-Atracotoxin has generated unprecedented debate. As we continue to explore this ever-evolving phenomenon, it is important to understand its ramifications and how it is shaping the world around us. In this article, we will delve into the different aspects of Omega-Atracotoxin, from its history to its impact today, in order to shed light on this topic and encourage informed discussion.
ω-Atracotoxin
Identifiers
SymbolOmega-toxin
PfamPF06357
InterProIPR009415
SCOP21hvw / SCOPe / SUPFAM
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary
PDB1hvwA:4-23 1axh :1-37

omega-Atracotoxin (ω-atracotoxin) is an insect-specific neurotoxin produced by the Blue Mountains funnel-web spider. Its phylogenetic specificity derives from its ability to antagonise insect, but not vertebrate, voltage-gated calcium channels. Two spatially proximal amino acid residues, Asn(27) and Arg(35), form a contiguous molecular surface that is essential for toxin activity. It has been proposed that this surface of the beta-hairpin is a key site for interaction of the toxin with insect calcium channels.

See also

References

  1. ^ King GF, Fletcher JI, Tedford HW (2001). "Functional significance of the beta hairpin in the insecticidal neurotoxin omega-atracotoxin-Hv1a". J. Biol. Chem. 276 (28): 26568–26576. doi:10.1074/jbc.M102199200. PMID 11313356.
This article incorporates text from the public domain Pfam and InterPro: IPR009415