Spiroxatrine

This document addresses the topic of Spiroxatrine from different perspectives with the aim of providing a comprehensive and complete vision of this topic of interest. Its historical aspects, its current implications, as well as possible future scenarios are analyzed. Through a multidisciplinary approach, the different angles from which Spiroxatrine has impacted or can impact in various contexts are explored. Likewise, various expert opinions are presented and a critical reflection is offered on the implications and challenges that Spiroxatrine poses for society as a whole. This article aims to contribute to the analysis and informed debate about Spiroxatrine, providing elements that enrich the understanding and dialogue around this topic.
Spiroxatrine
Names
IUPAC name
8-(2,3-Dihydro-1,4-benzodioxin-2-ylmethyl)-1-phenyl-1,3,8-triazaspirodecan-4-one
Identifiers
3D model (JSmol)
ChEMBL
ChemSpider
MeSH Spiroxatrine
UNII
  • InChI=1S/C22H25N3O3/c26-21-22(25(16-23-21)17-6-2-1-3-7-17)10-12-24(13-11-22)14-18-15-27-19-8-4-5-9-20(19)28-18/h1-9,18H,10-16H2,(H,23,26) checkY
    Key: JVGBTTIJPBFLTE-UHFFFAOYSA-N checkY
  • O=C2NCN(c1ccccc1)C23CCN(CC3)CC4Oc5ccccc5OC4
Properties
C22H25N3O3
Molar mass 379.460 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa).
☒N verify (what is checkY☒N ?)

Spiroxatrine is a drug which acts as a selective antagonist at both the 5-HT1A receptor and the α2C adrenergic receptor. It is an analog of spiperone and also has some dopamine antagonist effects.

References

  1. ^ Terrón, J. A.; Ibarra, M; Ransanz, V; Hong, E; Villalón, C. M. (1993). "The alpha-antiadrenergic properties of spiroxatrine, a ligand of serotonergic 5-HT1A receptors". Archivos del Instituto de Cardiología de México. 63 (4): 289–95. PMID 8105762.


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